| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Derek Carr |
1. Derek Carr, QB | LV | W 33-27 vs. BAL | 34 | 56 | 435 | 2 | 1 | 3 | 0 | 89.5 |
| 2. Dak Prescott, QB | DAL | L 31-29 at TB | 42 | 58 | 403 | 3 | 1 | 1 | 0 | 101.4 | |
| 3. Tom Brady, QB | TB | W 31-29 vs. DAL | 32 | 50 | 379 | 4 | 2 | 0 | 0 | 97.0 | |
| 4. Kirk Cousins, QB | MIN | L 27-24 at CIN | 36 | 49 | 351 | 2 | 0 | 3 | 0 | 106.8 | |
| 5. Jared Goff, QB | DET | L 41-33 vs. SF | 38 | 57 | 338 | 3 | 1 | 3 | 0 | 92.6 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Joe Mixon |
1. Joe Mixon, RB | CIN | W 27-24 vs. MIN | 29 | 127 | 4.4 | 1 | 19 | 0 | |
| 2. David Montgomery, RB | CHI | L 34-14 at LAR | 16 | 108 | 6.8 | 1 | 41 | 0 | ||
| 3. Elijah Mitchell, RB | SF | W 41-33 at DET | 19 | 104 | 5.5 | 1 | 38 | 0 | ||
| 4. Melvin Gordon III, RB | DEN | W 27-13 at NYG | 11 | 101 | 9.2 | 1 | 70 | 0 | ||
| 5. Damien Harris, RB | NE | L 17-16 vs. MIA | 23 | 100 | 4.3 | 0 | 35 | 1 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Tyreek Hill |
1. Tyreek Hill, WR | KC | W 33-29 vs. CLE | 11 | 197 | 17.9 | 1 | 75 | 0 | |
| 2. Deebo Samuel Sr., WR | SF | W 41-33 at DET | 9 | 189 | 21.0 | 1 | 79 | 1 | ||
| 3. Amari Cooper, WR | DAL | L 31-29 at TB | 13 | 139 | 10.7 | 2 | 28 | 0 | ||
| 4. Brandin Cooks, WR | HOU | W 37-21 vs. JAX | 5 | 132 | 26.4 | 0 | 52 | 0 | ||
| 5. Antonio Brown, WR | TB | W 31-29 vs. DAL | 5 | 121 | 24.2 | 1 | 47 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Eric Kendricks |
1. Eric Kendricks, LB | MIN | L 27-24 at CIN | 6 | 9 | 15 | 0.0 | 0 | 0 | 0 |
| 2. Bobby Wagner, LB | SEA | W 28-16 at IND | 6 | 7 | 13 | 0.0 | 0 | 0 | 0 | |
| 3. Jerome Baker, LB | MIA | W 17-16 at NE | 9 | 3 | 12 | 0.0 | 0 | 0 | 0 | |
| 4. Cole Holcomb, LB | WSH | L 20-16 vs. LAC | 7 | 4 | 11 | 0.0 | 0 | 0 | 0 | |
| 5. Fred Warner, LB | SF | W 41-33 at DET | 7 | 4 | 11 | 0.0 | 0 | 0 | 0 | |